Genotoxicity of tobacco smoke-derived aromatic amines and bladder cancer: current state of knowledge and future research directions
Besaratinia and Tommasi start of by providing background information on bladder cancer and how individuals in the United States tend to acquire bladder cancer at higher rates if they are smokers. Throughout their article they discuss the knowledge available surrounding DNA adduction and mutagenicity of aromatic amines and their correlating relationship to individuals who smoke and acquire bladder cancer. They go on to provide their thoughts on where research in the future needs to focus on specifically the mechanisms of tobacco smoke bladder carcinogenesis. Besaratinia and Tommasi specifically pinpoint this area of focus because by gaining a better understanding of bladder carcinogenesis substantial improvements can be in preventing, methods of early detection, treatments and prognosis’s of malignancy.
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